ISSN 1662-4009 (online)

ey0017.2-14 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB17

2.14. Gestational diabetes adversely affects pancreatic islet architecture and function in the male rat offspring

P Agarwal , N Brar , TS Morriseau , SM Kereliuk , MA Fonseca , LK Cole , A Jha , B Xiang , KL Hunt , N Seshadri , GM Hatch , CA Doucette , VW Dolinsky

To read the full abstract: Endocrinology. 2019 Aug 1;160(8):1907–1925. PMID: 31237608Gestational diabetes (GDM) is associated with impaired beta-cell function in the offspring and this leads to increased risk of type 2 diabetes mellitus (1). However, the underlying mechanisms are not well understood. GDM exposure may alter islet gene expression and function in the fetus. Impai...